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Rome Itineray - I've done most of my homework; Needs fine tuning!

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First trip to Rome and there is so much to see, but I don't want to be so busy that we don't experience the city. Some things are already booked and cast in stone. Everywhere else, there is a lot of flexibility. I am open to any and all suggestions for improvement and have also posted a few specific questions. We will be staying in an apartment in the Pantheon area. Thank you!

Restaurant suggestions and suggestions for the evenings particularly welcome!

DAY 1 - WEDNESDAY, MAY 22
Train arrives from Florence @ 1:30; Get to and settle in apt. Streets by 2:30.
Shop to stock apt., and explore immediate area
5:30: Twilight Tour of Rome with Walks of Italy BOOKED (gives an overview of the historical district).
8:00: On our own – dinner and back to apt.

DAY 2 - THURSDAY, MAY 23
8:30 - Colosseum, Roman Forum, and Palantine Hill 3 ½ hour tour with Walks of Italy – BOOKED
QUESTION: What is the best/fastest way to get from Pantheon area to metro stop at the Colosseum? I’ve read that walking is faster than buses or going all the way to Termini to get the metro back to the Colosseum. Opinions, please!
AFTERNOON – Walk to Jewish Quarter for lunch and explore. Afternoon and evening are open. Suggestions??

DAY 3 - FRIDAY, MAY 24
MORNING - 9:00 AM – Scavi Tour Booked 1 ½ hours.
10:45 – 12:30: Go to Castel Sant'Angelo, see that, take in the view, have lunch, and head back to the Vatican.
QUESTION: Is there enough time to do this and get back to the Vatican for 12:45???
1:00 - 3.5 hour Vatican Museum and Sistene Chapel Tour with Through Eternity – BOOKED
QUESTION: After the tour should we go to top of dome? I don’t feel the need to go to the top of everything, but I don’t want to miss those opportunities that are really special.
EVENING: Open

DAY 4 - SATURDAY, MAY 25
MORNING - Campo di Fiori and wandering the shopping areas of Rome – Spanish Steps area, etc.
AFTERNOON: Explore Trastevere
EVENING: Open

DAY 5 – SUNDAY, MAY 26
MORNING: Find a cool church and go to Mass
AFTERNOON - Borghese Gallery & Gardens, Piazza del Poppolo
EVENING: Open – Last night in Europe :(

DAY 6 – MONDAY, MAY 27 – Early flight home, leave apt. at 6:30am for 9:30 flight.
QUESTION: BEST/MOST RELIABLE TRANSPORATION? I don't mind hiring a car, but would feel better with a recommendation.

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