Interstate 75 spans the region from north to south. Once you cross the Florida border from Georgia, it should take about 4 1/2 hours to reach Tampa and another hour to reach Sarasota. Interstate exits are numbered according to mileage from their southern terminus, rather than sequentially. Coming from Orlando, you're likely to drive west into Tampa on Interstate 4. Along with Interstate 75, U.S. 41 (which runs concurrently with the Tamiami Trail for much of the way) stretches the length of the region. U.S. 41 links the business districts of many communities, so it's best to avoid it and all bridges during rush hours (7-9 AM and 4-6 PM). U.S. 19 is St. Petersburg's major north-south artery; traffic can be heavy, and there are many lights, so use a different route when possible. Interstate 275 heads west from Tampa across Tampa Bay to St. Petersburg, swings south, and crosses the bay again on its way to Terra Ceia, near Bradenton. Along this last leg -- the Sunshine Skyway and its stunning suspension bridge -- you'll get a bird's-eye view of bustling Tampa Bay. The Gandy Bridge (Highway 92) also yields a spectacular view of Tampa Bay, and Route 679 takes you along two of St. Petersburg's most pristine islands, Cabbage and Mullet keys. Route 64 connects Interstate 75 to Bradenton and Anna Maria Island. Route 789 runs over several slender barrier islands, past miles of blue-green gulf waters, beaches, and waterfront homes. The road does not connect all the islands, however; it runs from the village of Anna Maria off the Bradenton coast south to Lido Key, then begins again on Siesta Key and again on Casey Key south of Osprey, and runs south to Nokomis Beach.
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