Grand Hotel Vesuvio
You'd never guess from the blandly modern exterior that this is the oldest of the city's great seafront hotels—the place where Enrico Caruso died, where Oscar Wilde dallied with lover Lord Alfred Douglas, and where Bill Clinton charmed the waitresses—but, fortunately, the spacious, soothing interior compensates for what's lacking on the outside. Guest rooms, the best of which overlook the bay, are luxurious and traditional, with antique accents, vibrantly colored walls, and gleaming bathrooms. On-site amenities include the famous Caruso restaurant, the rooftop Sky Lounge, a small gym, and a spa with myriad (though pricey) pampering services.